Journal Reviews

Otolaryngology Clinics of North America journal cover image.

How best can we manage Samter’s Triad/AERD?

3 July 2023 | | Rhinology / Sinus | Aspirin intolerance, Aspirin-exacerbated respiratory disease, Asthma, Biological agents, Chronic rhinosinusitis with nasal polyposis, NSAID intolerance, Samter's Triad

The classic ‘Samter’s Triad’ of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and aspirin sensitivity is now referred to as aspirin-exacerbated respiratory disease (AERD) or non-steroidal anti-inflammatory-exacerbated respiratory disease. We often come across in our rhinology setting, patients with recalcitrant...

American Journal of Rhinology & Allergy cover image.

Serum biomarkers for CRSwNP

5 January 2022 | | ENT, Maxillofacial Surgery, Rhinology / Sinus | Lund Mackay score, Pentraxin-3, Sinonasal Outcome Test 22, biomarkers, chronic rhinosinusitis with nasal polyposis, immunoglobulin E, interleukin-17, polyposis recurrence, sinusitis

This cross-sectional comparative study looked at 50 patients with nasal polyps who, at the time of diagnosis, also had a blood test evaluating serum total IgE, IL-17 and Pentraxin-3. The study assesses whether these blood markers are useful in the...

INTERNATIONAL FORUM OF ALLERGY AND RHINOLOGY cover image

The search for the holy grail of rhinosinusitis: another step towards phenotyping in CRS wNP?

7 January 2020 | | Maxillofacial Surgery, Rhinology / Sinus | allergy, asthma, central compartment atopic disease, chronic rhinosinusitis, nasal polyposis

For many years, scientists and clinicians have been trying to understand the infinite variability within the term ‘rhinosinusitis’ using radiology, basic science, epidemiology and then using their insights to solve the riddle of management: how to explain why some patients...

ALLERGY cover

CRSwNP, another monoclonal antibody

1 July 2019 | | Rhinology / Sinus | biomarkers, dupilumab, nasal polyposis, nasal secretions, type 2 inflammation

Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...